DECODING GENOME

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Bioinformatics · Genomics · Computational Biology

Nika Hasanzad

MSc Bioinformatics Candidate | Genomics, RNA-Seq & Computational Biology

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About Me

Bridging biology and computation

A researcher translating raw sequencing data into biological insight — from wet-lab genomics to reproducible computational pipelines.

I'm an MSc Bioinformatics candidate focused on genomics, RNA-Seq and computational biology. My work spans the full arc of modern genomics — from molecular wet-lab techniques to building reproducible analysis pipelines that turn sequencing reads into clinical and biological meaning.

I'm driven by precision medicine and the potential of multi-omics and AI to reshape how we understand disease.

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Python
Data pipelines & analysis
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RNA-Seq
Differential expression
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NGS Analysis
Short-read workflows
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Pipelines
Reproducible workflows

Journey

  1. 2024

    Tehran Medical Sciences Internship

    Medical Genomic Research Center — wet-lab genomics & molecular biology.

  2. 2024 – 2025

    Bioinformatics Training

    Statistical modelling, genomics, NGS and applied analysis intensives.

  3. 2025 – 2027

    University of Birmingham — MSc

    MSc Bioinformatics Candidate, computational & translational genomics.

Technical Skills

The skill galaxy

Hover any node to reveal proficiency. Filter by category to explore clusters of connected expertise.

Proficiency

Hover a node in the galaxy to inspect a skill.
Research Experience

Selected projects

Translational Genomics01

Integrative RNA-Seq & Clinical Data Analysis

Objective
Link transcriptomic signatures to clinical phenotypes to surface candidate prognostic biomarkers.
Methods
QC → alignment (STAR) → quantification (Salmon) → DESeq2 differential expression → clinical covariate modelling.
Tools
STARSalmonDESeq2RPython
Expected Outcomes
Ranked differentially expressed genes correlated with clinical outcome and enriched pathways.
Multi-omics02

Microbiome & Precision Immunotherapy Research

Objective
Explore how microbiome composition associates with immunotherapy response signatures.
Methods
Taxonomic profiling, diversity metrics, host transcriptome integration and statistical association testing.
Tools
QIIME2RPythonBioconductor
Expected Outcomes
Identified microbial features and host pathways associated with treatment response stratification.
Sequencing Pipelines03

NGS Data Analysis

Objective
Build a reproducible NGS workflow from raw reads to annotated, analysis-ready variants.
Methods
FastQC/MultiQC QC → alignment → variant calling → annotation → IGV visual validation.
Tools
FastQCMultiQCHISAT2GATKIGV
Expected Outcomes
Reproducible, documented pipeline producing high-confidence annotated variant sets.
Transcriptomics04

RNA-Seq Data Analysis

Objective
Characterize gene expression changes across conditions with rigorous statistical control.
Methods
Pseudo-alignment (Kallisto), normalization, DE testing, GSEA and volcano/PCA visualization.
Tools
KallistoRSEMedgeRggplot2
Expected Outcomes
Clear expression landscapes, enriched gene sets and publication-ready figures.
Bioinformatics Visualization

Data, brought to life

A genome-browser-inspired view of the analyses I work with — every chart animates as it enters the viewport.

Expression Heatmap

Genes × samples · z-scored

Volcano Plot

Differential expression

PCA Plot

Sample clustering · PC1 / PC2

Gene Expression

Normalized counts (TPM)

Molecular Interaction Network

Gene–gene co-expression graph

Internship Experience

Inside the genomics lab

FEB 2024 – AUG 2024

Medical Genomic Research Center

Tehran Medical Sciences, Islamic Azad University

Hands-on molecular biology and genomics — from sample preparation and nucleic-acid extraction to amplification, quantification and research support across active projects.

PCR
Real-Time PCR
Cell Culture
DNA / RNA Extraction
Research Assistance
Education Timeline

Academic trajectory

Scroll to illuminate the path — formal study and intensive bioinformatics training.

Oct 2025 – Oct 2027In progress

MSc Bioinformatics Candidate

University of Birmingham

Computational genomics, machine learning for biology, and translational research.

Training

Essentials in Statistical Modelling

Bioinformatics Training

Regression, inference and experimental design for omics data.

Training

Introduction to Genomics and NGS

Bioinformatics Training

Foundations of sequencing technologies and genomic data.

Training

Applied Genomics and NGS

Bioinformatics Training

Hands-on alignment, variant calling and expression workflows.

Publications & Future Research

Where I'm heading

Research directions I'm actively pursuing at the intersection of genomics, medicine and artificial intelligence.

Cancer Genomics

Decoding tumor heterogeneity and driver mutations from sequencing data.

Multi-omics

Integrating genomic, transcriptomic and microbiome layers into unified models.

Precision Medicine

Translating molecular profiles into individualized therapeutic insight.

AI for Biology

Deep learning for sequence, structure and expression prediction.

Biomarker Discovery

Surfacing robust, reproducible signatures of disease and response.

Publications

Manuscripts in preparation. Forthcoming work will explore transcriptomic biomarkers and multi-omics integration.

Coming soon
Contact

Let's build something meaningful

Open to research collaborations, PhD opportunities and roles in genomics & computational biology.

Location
Birmingham, United Kingdom